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Researchers create lung 'blueprint' that could aid organ regeneration

人造器官将现实，科学家成功绘制人类肺部细胞蓝图

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Serious lung disease has a high rate of mortality, and the only curative treatment is a lung transplant. This is a complicated procedure that has other adverse health effects and oftentimes simply doesn't work, so for scientists in this field, organ regeneration -- that is, growing an organ from the body's own tissue -- is the ultimate solution.

Now, researchers from Yale say they're on track for this very eventuality.

严重的肺部疾病死亡率高，唯一的治疗方法是肺转移。这是一个复杂的过程，还会产生其他副作用，并且通常完全不起作用。因此，


对于这一领域的科学家来说，器官再生——也就是从人体自身组织中培育出一个器官——是最终的解决方案。

现在，耶鲁大学的研究人员表示，他们正在为这种可能性而努力。

Using sophisticated screening processes, the team has created a cellular blueprint of the human lung, making it easier to understand the design of lung function and respiratory diseases. The technology offers an ultrahigh resolution of millions of cells at once.

通过复杂的筛选过程，研究小组绘制除了人类肺部的细胞蓝图，使人们更容易理解肺功能和呼吸系统疾病的设计。这项技术能同时提供 数百万个细胞的超高分辨率。

Professor Naftali Kaminski of the Yale School of Medicine explained that this has only been possible thanks to advances in resolution technology. "It's like we have moved the resolution on cell analysis from looking at the night sky with the naked eye, to a child's telescope, to an observatory and, now, the Hubble telescope," he said.

耶鲁大学医学院的纳夫塔利·卡明斯基教授解释说，这完全归功于分辨技术的进步。他说“这就像我们把细胞分析的分辨率从肉眼观察夜空的方式，提高到了儿童望远镜、天文台，现在又提高到了哈勃望远镜。”

The blueprint will provide researchers with detailed information on the way lung cells interact, and will also help in finding new molecular targets for therapies to treat lung diseases such as pulmonary fibrosis.

该蓝图将为研究人员提供相关肺细胞相互作用方式的详细信息，海将有助于寻找治疗肺疾病（如肺纤维化） 的新分子靶点。

According to the team, there are active bioengineering efforts taking place that aim to grow lung tissue in specially adapted glass jars. The new blueprints will help researchers determine whether or not their lab-grown tissue is on track to become an actual organ, and provide some insight into any changes that need to be made.

据研究小组称，正在进行积极的生物工程努力，目的是在特制的玻璃瓶中培养


肺组织。新的蓝图将帮助研究人员确定他们的实验室培养的组织是否有望成长为真正的器官，并未需要做出的任何改变提供一些见解。

“We're looking at the basic principles of the development of an organ," Kaminski said. "Applying this approach could allow us to design new organs."

“我们正在研究器官发育的基本原理，”卡明斯基说，“应用这种方法可以让我们设计出新的器官。”